Iomega, a US-based manufacturer of disk drives for the computer industry, will make 30 staff redundant at its customer support centre located in Dublin.
The company is also looking for a smaller site for its shrinking workforce, which will fall to 12 people by the end of the year, down from an all-time high of 80 staff in August last year.
Mr Martin Schoppler, general manager for Ireland, said the company may find another location at the Citywest business park - or it could go somewhere else.
When Iomega let a 22,500 sq ft facility in Citywest in 1998 to expand from a previous base in Swords, it was the largest tenant in the business park.
The company continues to outsource some support functions to Swords-based business Clientlogic.
The latest redundancies follow Iomega's decision last week to cut 38 per cent of its global workforce due to falling sales and greater competition in the disk drive business.
The company, which supplies equipment to Gateway Ireland's doomed manufacturing plant in Clonshaugh, will shed 1,200 jobs this quarter, leaving just 2,025 staff worldwide.
Iomega's global restructuring was detailed last week, when the firm said it expected to record restructuring charges in the range of $55 million (€60 million) to $65 million in the third quarter.
Iomega chief executive Mr Werner Heid said the company's goal in the short term was to significantly lower the break-even point of the business, stop the revenue decline and improve operational efficiency.
Iomega opened its European customer support centre in Swords in 1995, providing technical support to 16 European countries and South Africa.
During the past year it has experienced a downturn in global demand due to the global economic slowdown and has steadily reduced its workforce.
Mr Schoppler said the company would continue to support all its customers in the European region and there was no plan to exit the region altogether.
He said all the Irish staff who had been made redundant had received "very adequate" redundancy packages.
However, he would not release details of those redundancy packages.