The Taoiseach Bertie Ahern flies to New York today for a United Nations meeting on Aids.
The meeting will review progress since the first UN Special Session on HIV/Aids in June 2001.
The UN member states, including Ireland, signed a Declaration of Commitment to HIV/Aids at that meeting.
Mr Ahern is due to address the UN General Assembly on Friday.
Taoiseach Bertie Ahern
He is due to meet UN Secretary General Kofi Annan tomorrow, when he will present him with a report of the Government's response to the challenge of HIV/Aids in developing countries, from 2001 to the present.
A Government spokesman said he will reiterate Ireland's commitment to reach the UN target of spending 0.7 per cent of GNP on official development assistance by the year 2012.
The Government made a commitment in September 2005 to increase its spending on HIV and poverty-related diseases to €100 million per year.
Speaking before leaving for the US, Mr Ahern said: "The fight against AIDS remains one of the greatest challenges of our generation. We will be judged by the generosity of our response, and by the strength of our leadership."
The high-level meeting will include world-wide heads of state, representatives from civil society and from the private sector.
Mr Ahern will be joined by an Irish delegation that includes Minister of State for Development Cooperation Conor Lenihan.
The Taoiseach will also meet Irish business leaders and attend business-related events organised by Enterprise Ireland.