Demonstrators opposed to efforts by Bolivian President Evo Morales to overhaul the constitution have torched police stations and stormed a jail, freeing 100 inmates, while on the streets protesters clashed with police and one officer was killed.
The protests in the southern city of Sucre came hours after pro-government allies in a constitutional assembly approved a preliminary draft late on Saturday of the new constitution, a key Morales political project.
Mr Morales, a leftist and Bolivia's first Indian president, says the new constitution will give the country's indigenous majority more political power. But the vote was boycotted by the rightist opposition, which has heavily criticized the assembly.
On the streets of Sucre, protesters stood face to face with police officers, setting fires to tires as tear-gas rained down on them.
They also set fire to Sucre's San Roque prison, starting a prison riot that saw at least 100 inmates escape, local media said.
Bolivia's state news agency ABI reported police had been ordered off the streets in Sucre to avoid further provoking protesters. The agency said the police officer who was killed had been lynched by a mob. Three other officers were injured.
Protests have raged for days against the assembly and the constitution it was drafting, and on Saturday police used tear gas and rubber bullets to disperse thousands of demonstrators armed with rocks and clubs.
The assembly has polarized the country and comes amid a power struggle between Morales and his conservative rivals, who want more autonomy for the regions they govern and who also want to move the seat of government and Congress to Sucre from La Paz, a bastion of support for the president.