Saturday February 14th
Fulham v West Ham
Alain Goma returns from a hamstring strain and takes over from the cuptied Ian Pearce. Lee Clark (Achilles) misses out and Facundo Sava and Mark Pembridge (both calf) and Collins John (ankle) are still sidelined. Jerome Bonnissel will undergo ankle surgery this weekend and is out for the rest of the season.
Bobby Zamora, Andy Melville, Jobi McAnuff, Nigel Reo-Coker and Adam Nowland are all cup-tied and miss out for West Ham, while loan signing Jon Harley has been refused permission to play against his parent club.
Top scorers: Luis Boa Morte (Fulham) 6; David Connolly (West Ham) 11
Match odds: H 4-6 A 7-2 D 23-10
Referee: G Poll (Hertfordshire)
Man Utd v Man City
Gary Neville is set to add some defensive steel to the Manchester United line-up after missing the home league defeat to Middlesbrough with a slight thigh strain. Roy Keane should also return while Ole Gunnar Solskjaer has an outside chance of being on the bench. Louis Saha is cup-tied.
City are without Nicolas Anelka who has failed to recover from a groin strain and Jon Macken is likely to partner Robbie Fowler up front. Iceland goalkeeper Arni Arason is set to return as David James is ineligible. Sun Jihai is away on World Cup duty for China while Trevor Sinclair remains sidelined with a calf injury.
Top scorers: Ruud van Nistelrooy (Man Utd) 22; Nicolas Anelka (Man City) 19
Match odds: H 1-3 A 7-1 D 3-1
Referee: J Winter (Cleveland)
Sunderland v Birmingham
Sunderland new boy Darren Byfield will be forced to watch the tie as he is cup-tied after playing for former club Rotherham in the earlier rounds. Striker Marcus Stewart, who missed the fourth-round victory over his old club Ipswich through suspension, is available.
Birmingham are without £1.25million central defender Martin Taylor, who is cup-tied. Midfielders David Dunn and Stephen Clemence are also out with groin and calf problems respectively.
Top scorers: Marcus Stewart (Sunderland) 11; Mikael Forssell (Birmingham) 10
Match odds: H 7-4 A 13-10 D 21-10
Referee: G Barber (Hertfordshire)
Millwall v Burnley
Danny Dichio will lead the line for Millwall after completing his transfer from West Brom. Andy Marshall starts in goal after missing the fourth-round win over Telford because he had not signed in time.
Burnley striker Robbie Blake is back and goes straight into the starting line-up after suspension kept him out of last Saturday's win over Gillingham.
Top scorers: Tim Cahill, Daniele Dichio, Neil Harris & Paul Ifill (Millwall) 5; Robert Blake (Burnley) 17
Match odds: H 4-5 A 7-2 D 23-10
Referee: H Webb (S Yorkshire)
Tranmere v Swansea
Mickey Mellon is Tranmere's major absentee. The midfielder serves a one-game ban for his sending-off against Colchester, but manager Brian Little is buoyed by the return to fitness of Steven Jennings (knee), Paul Linwood (groin) and Chris Dagnall (hamstring).
Kevin Nugent and Karl Connolly are both doubtful for Swansea. Nugent sustained an ankle injury last weekend while Connolly injured his ankle in training. James Thomas and Lenny Johnrose are also doubts.
Top scorers: Eugene Dadi (Tranmere) 10; Lee Trundle (Swansea) 19
Match odds: H 4-6 A 10-3 D 12-5
Referee: R Beeby (Northamptonshire)
Sunday February 15th
Arsenal v Chelsea
Dennis Bergkamp returns to Arsenal's squad after missing last week's Premiership game at home to Southampton with a calf injury. Manager Arsene Wenger still without injured trio Sylvain Wiltord, Freddie Ljungberg and Jeremie Aliadiere.
Chelsea expect to welcome back Carlo Cudicini, who has missed two matches with a groin strain. Hernan Crespo is looking to prove his fitness after his impressive midweek scoring comeback as a substitute against Portsmouth.
Top scorers: Thierry Henry (Arsenal) 24; Jimmy Floyd Hasselbaink (Chelsea) 13
Match odds: H 1-1 A 23-10 D 21-10
Referee: P Durkin (Dorset)
Liverpool v Portsmouth
Gerard Houllier has ruled out a Milan Baros comeback on Sunday. Baros, sidelined for five months after breaking his ankle, was on target for the reserves in midweek but Houllier will not rush him back. Chris Kirkland is fit to take his place on the bench after a scan revealed he did not sustain any damage to his back during the Villa match.
Portsmouth will be without injured trio Teddy Sheringham, Steve Stone and former Liverpool star Patrik Berger. Harry Redknapp must also cope without new signings John Curtis and Lomano LuaLua, who are cup tied. Alexei Smertin is available again after his parent club Chelsea insisted he did not play against them in midweek.
Top scorers: Michael Owen (Liverpool) 10; Aiyegbeni Yakubu (Portsmouth) 8
Match odds: H 4-11 A 7-1 D 11-4
Referee: M Halsey (Lancashire)
Sheff Utd v Colchester
Sheffield United will be without Carl Robinson and Paul Shaw. Midfielder Robinson, on loan from Portsmouth, and former Gillingham skipper Shaw are both cup-tied.
Colchester will be without Craig Fagan and Jamie Cade. Fagan completes a two-match suspension and Cade is cup-tied after making an appearance for Chesterfield earlier in the competition.
Top scorers: Jack Lester (Sheff Utd) 11; Scott McGleish (Colchester) 14
Match odds: H 2-5 A 13-2 D 13-5
Referee: D Pugh (Merseyside)