Veteran forward Carlo Checchinato is the principal doubt for Italy for their last RBS 6 Nations match with Wales at the Millennium Stadium.
Checchinato, who in Saturday's 19-3 defeat by Ireland equalled Alessandro Troncon's record of 83 caps for the Azzurri, has already announced he will end his 14-year international career after Saturday's match.
He was named in the provisional starting line-up for the match with Wales but Roberto Mandelli stands by to fill the number eight jersey in case Checchinato does not make it.
Checchinato sustained an injury to a bone in his left foot during Sunday's game with the Irish.
Fabio Ongaro will start as hooker although it is not clear whether Stefano Saviozzi or Carlo Festuccia will deputise on the bench.
It was Festuccia whose disastrous line-out throw allowed Malcolm O'Kelly to score a game-changing try for Ireland in Dublin.
Italy have stayed in Ireland ahead of their match in Cardiff but departed for Wales on Wednesday.
Ongaro and Santiago Dellape both needed treatment for their respective injuries but should play on Saturday.
Full team and replacements
15 -Gonzalo Canale; 14-Nicola Mazzucato, 13-Andrea Masi, 12-Cristian Stoica, 11-Denis Dallan; 10-Roland De Marigny, 9-Paul Griffen; 8-Carlo Checchinato or Roberto Mandelli, 7-Aaron Persico, 6-Andrea De Rossi, 5-Marco Bortolami, 4-Santiago Dellape, 3-Martin Castrogiovanni, 2-Fabio Ongaro, 1-Andrea Lo Cicero.
Replacements: 16-Stefano Saviozzi or Carlo Festuccia, 17-Salvatore Perugini, 18-Carlo Antonio Del Fava, 19-Silvio Orlando, 20-Simon Picone, 21-Rima Wakarua, 22-Mirco Bergamasco.