Manchester United defender Mikael Silvestre has an ankle injury and will miss tomorrow's Premiership clash with Bolton at the Reebok Stadium.
Silvestre limped out of Wednesday's Champions League win over Juventus and Republic of Ireland international John O'Shea is likely to take his place.
Paul Scholes is a doubtful starter after aggravating a groin injury in the same game.
David Beckham and Ryan Giggs are thought to be carrying minor knocks, but Juan Sebastian Veron, who was suspended for the Juventus game, has declared his fitness after missing two games with a toe injury.
Goalkeeper David Seaman is ruled out of Arsenal's trip to Manchester City with a hip injury sustained in the midweek Champions League draw against Ajax.
Seaman, who could recover in time for the return European fixture in Amsterdam, will be replaced at Maine Road by Stuart Taylor, while Freddie Ljungberg is still ruled out with a persistent Achilles problem.
Martin Keown is a further doubt with a back injury which forced him to miss the Ajax game, while Oleg Luzhny also faces a fitness test on a calf problem.
Gianfranco Zola may have to start his 300th Chelsea game as a substitute when Blackburn Rovers visit Stamford Bridge.
Zola has fully recovered from a hamstring injury sustained at Birmingham two weeks ago and boss Claudio Ranieri must decide whether to break up the Jimmy Floyd Hasselbaink-Eidur Gudjohnson partnership to accommodate the popular veteran.
Captain Marcel Desailly and reserve goalkeeper Ed de Goey are still out injured while midfielder Emmanuel Petit serves a one-match suspension.
Celestine Babayaro is avalable again, however, after three games out with a thigh injury.
Alan Shearer and Craig Bellamy will return from European suspension to spearhead Newcastle's attack at Leeds.
Youngsters Shola Ameobi and Lomana LuaLua, who did so well at Bayer Leverkusen in midweek, are likely to make way, while midfielder Nolberto Solano remains sidelined with a thigh strain.
French full-back Olivier Bernard is suspended and Andy Griffin will get his chance after recovering from an elbow injury.