Spurs, who were knocked out by the eventual winners, Seville, in the Uefa Cup quarter-finals last season, will kick off the new European campaign against Cypriot side Anorthosis Famagusta, who have former Southampton striker Marian Pahars in their ranks.
After yesterday's draw in Monaco, Tottenham's sporting director Damien Comolli said: "They won their domestic cup and came third in their league so they must be a decent team.
"For us the Uefa Cup is a big thing and we will try to do better than last year. We were all frustrated that we didn't go through against Seville because everyone knew whoever would win that tie would probably win the competition and that's what happened."
Everton were paired with Metalist Kharkiv from Ukraine, who finished third in their domestic league last season, andwill play the first leg at Goodison Park.
Blackburn will play Greek cup winners Larissa, managed by former Rovers winger Georgios Donis and with former Everton striker Ibrahima Bakayoko in the squad.
Bolton are up against Macedonian league runners-up FK Rabotnicki, while Aberdeen, Scotland's only representatives in the competition, face Ukrainian opposition in Dnipro Dnipropetrovsk.
Meanwhile, with a week remaining before the Republic of Ireland's Euro 2008 qualifyier in Slovakia, Steve Staunton will hope his squad members avoid injury over the weekend.
Ireland play Slovakia next Saturday and the Czech Republic on Wednesday, September 12th.
Concerns have been raised before a ball has been kicked: midfielder Lee Carsley is rated doubtful for Everton's trip to Bolton Wanderers, while striker Shane Long has a broken thumb and may not start Reading's home fixture with West Ham United.
Chelsea and England midfielder Frank Lampard has torn a muscle in his left thigh.
Lampard suffered the injury in training on yesterday, with a hospital scan confirming the tear.
"It is too early to say how long the injury will keep him from playing," the statement said.
Earlier yesterday, Lampard was named in Steve McClaren's England squad for the next two Euro 2008 qualifiers against Israel and Russia in the next two weeks, but his participation in those games is now in doubt.
Steven Gerrard has indicated to Steve McClaren he would be willing to have pain-killing injections to get him through the crucial double-header.
Gerrard will not play for Liverpool against Derby at Anfield tomorrow but will join up with the England squad, according to Liverpool manager Rafael Benitez.
UEFA CUP - First round draw (ties to be played on Sept 20th and Oct 4th): FC Midtjylland v Lokomotiv Moscow, FC Groningen v Fiorentina, Rabotnicki Kometal v Bolton, AEK Athens/Sevilla v SV Red Bull, Nurnberg v Rapid Bucuresti, Everton v FC Metalist Kharkiv, Zenit St Petersburg v Standard L, Bayer Leverkusen v Uniao Leiria, Villarreal v BATE, FC Sion v Galatasaray, Atletico Madrid v Kayseri Erciye, Bordeaux v Tampere United, Panathinaikos v Artmedia Bratisl, Sparta Prague v Odense BK, FC Zurich v Empoli, Sochaux v Panionios, Rapid Vienna v Anderlecht, Pacos Ferreira v AZ, Sampdoria v AaB, Spartak Moscow v BK Hacken, Hammarby v Braga, Larissa v Blackburn, Mlada Boleslav v Palermo, Dinamo Zagreb v Ajax, Rennes v Lokomotiv Sofia, SK Brann v Club Brugge, Bayern Munich v Belenenses, Aberdeen v Dnipro, Heerenveen v Helsingborgs, IF Toulouse v CSKA Sofia, Hamburg v Litex Lovech, FK Sarajevo v Basle, FK Austria Magna v Valerenga, AIK Solna v Hapoel Tel Aviv, Aris Salonika v Real Zaragoza, Dinamo Bucuresti v IF Elfsborg, Tottenham v Anorthosis Famagusta, Lens v FC Copenhagen, Getafe v FC Twente Groclin Dyskobolia v Crvena Zvez.
ENGLAND SQUAD (for Euro 2008 qualifiers against Israel on Sept 8th and Russia on Sept 12th): Robinson (Tottenham), James (Portsmouth), Carson (Aston Villa), Richards (Manchester City), P Neville (Everton), Ferdinand (Manchester Utd), Terry (Chelsea), Campbell (Portsmouth), A Cole (Chelsea), Shorey (Reading), Brown (Manchester Utd), Barry (Aston Villa), Wright-Phillips (Chelsea), Bentley (Blackburn), Gerrard (Liverpool), Hargreaves (Manchester Utd), Lampard (Chelsea), Carrick (Manchester Utd), Downing (Middlesbrough), J Cole (Chelsea), Owen (Newcastle), Crouch (Liverpool), Smith (Newcastle), Johnson (Everton), Defoe (Tottenham), A Young (Aston Villa).
