Saturday
Arsenal (3) v Bolton (1)
Tony Adams has eased Arsenal's defensive injury crisis by making a surprise return to training and will partner Gilles Grimandi. Right-back Lee Dixon is still out after a cartilage operation but Oleg Luzhny has recovered from a knee ligament problem and comes in.
Rod Wallace could start after coming off the bench and marking his debut in midweek with a goal against Blackburn. The 31-year-old striker showed he had lost little of his sharpness despite training on his own for three months.
Last season: No corresponding fixture.
Last five league matches: Arsenal W L W D W, Bolton W W D L D.
Top scorers: Thierry Henry (Arsenal) 6 Michael Ricketts (Bolton) 4.
Match odds: H 2-7 A 7-1 D 7-2.
Referee: C Wilkes (Gloucester)
Blackburn (12) v Everton (9)
Graeme Souness is trying to sign a left-sided defender because of injuries to Martin Taylor, Craig Short and John Curtis. Souness is also without injured duo Keith Gillespie and David Dunn.
Everton boss Walter Smith has injury worries over Scot Gemmill, Mark Pembridge, Alessandro Pistone and Niclas Alexandersson. Tomasz Radzinski is in the squad and could start for the first time.
Last season: No corresponding fixture.
Last five league matches: Blackburn D W L D D, Everton W D W L L.
Top scorers: Matt Jansen (Blackburn) 2 Kevin Campbell and Duncan Ferguson (Everton) 3.
Match odds: H 10-11 A 5-2 D 11-5.
Referee: G Barber (Tring).
Leicester (18) v Fulham (15)
Wales midfielder Matthew Jones is a doubt after having six stitches in a head wound. Muzzy Izzet and James Scowcroft are also doubtful but Gary Rowett could return after a knee injury.
Fulham's £11.5million man Steve Marlet (right) is likely to make his full debut after recovering from knee injury. He is expected to start up front alongside Louis Saha but Alain Goma is still out with a hip problem.
Last season: No corresponding fixture.
Last five league matches: Leicester L L D W L, Fulham L W D D L.
Top scorers: Dean Sturridge (Leicester) 3; Louis Saha (Fulham) 3.
Match odds: H 2-1 A 11-10 D 11-5.
Referee: E Wolstenholme (Blackburn).
Liverpool (11) v Tottenham (7)
Liverpool are without Steven Gerrard, who starts a three-match suspension, and, with Dynamo Kiev due at Anfield next Wednesday in the Champions League, the likes of Jari Litmanen, Robbie Fowler, Vladimir Smicer, Jamie Redknapp and Nick Barmby could figure at some point.
Tottenham have named an unchanged squad. Manager Glenn Hoddle was delighted with the 2-1 win at Sunderland on Wednesday.
Last season: Liverpool 3 Tottenham 1, Tottenham 2 Liverpool 1.
Last five league matches: Liverpool W W L L W, Tottenham D L W L W.
Top scorers: Michael Owen (Liverpool) 9; Teddy Sheringham and Christian Ziege (Liverpool) 3.
Match odds: H 1-2 A 5-1 D 12-5.
Referee: M Riley (Leeds)
Man Utd (5) v Ipswich (14)
Ole Gunnar Solskjaer could have played himself into a starting place against Ipswich after impressing as a late substitute in the Champions League clash with Lille. Gary Neville (below) is could be ruled out after suffering concussion against the French outfit but Andy Cole is included in the squad.
Ipswich will use the same squad on duty for last night's UEFA Cup tie against Torpedo Moscow. Alun Armstrong (concussion) will miss out, but Italian keeper Matteo Sereni will play after his red card for an incident with Robbie Savage at Leicester last weekend has been rescinded.
Last season: Man Utd 2 Ipswich 0, Ipswich 1 Man Utd 1.
Last five league matches: Man Utd W D D W L, Ipswich L W L D D.
Top scorers: David Beckham and Ruud van Nistelrooy (Man Utd) 4; Finidi George (Ipswich) 2.
Match odds: H 1-4 A 9-1 D 7-2.
Referee: N Barry (Scunthorpe).
Sunderland (8) v Charlton (17)
Sunderland manager Peter Reid awaits fitness checks on goalkeeper Thomas Sorensen (nose) and defender George McCartney (groin) before naming his side. Jurgen Macho is set to continue in goal with Darren Williams standing by to replace McCartney in central defence.
Charlton hope to have last season's leading scorer Jonatan Johansson back after three matches out with an injured ankle. Club captain Mark Kinsella could also start, having returned to action as a substitute last week following a hernia operation in the summer.
Last season: Sunderland 3 Charlton 2, Charlton 0 Sunderland 1.
Last five league matches: Sunderland L D W D L, Charlton L L W D L.
Top scorers: Kevin Phillips (Sunderland) 4 John Fortune, Jonatan Johansson, Paul Konchesky and Kevin Lisbie (Charlton) all 1.
Match odds: H 8-13 A 4-1 D 23-10.
Referee: A D'Urso (Billericay).
Sunday
Chelsea (6) v Middlesbrough (13)
Chelsea have concerns over Marcel Desailly (ankle) and Jesper Gronkjaer (calf), who both missed the club's UEFA Cup first round tie against Levski Sofia on Thursday but they are said to be on the mend.
Middlesbrough striker Alen Boksic could return to action for the first time since the opening day of the season after finally shaking off a troublesome calf injury to take his place in Steve McClaren's squad.
Last season: Chelsea 2 Middlesbrough 1, Middlesbrough 1 Chelsea 0.
Last five league matches: Chelsea W D W D W, Middlesbrough L L L W W
Top scorers: Jimmy Floyd Hasselbaink (Chelsea) 4 Colin Cooper, Brian Deane, Jonathan Greening, Paul Ince, Allan Johnston, David Murphy, Szilard Nemeth and Mark Wilson (Middlesbrough) all 1.
Match odds: H 4-9 A 11-2 D 13-5.
Referee: R Styles (Waterlooville).
Leeds (2) v Derby (16)
Leeds manager David O'Leary will again be without injured duo Alan Smith (ankle) and Olivier Dacourt (hamstring) - but midfielders Lee Bowyer (below) and Eirik Bakke return from a European suspension and injury respectively.
Derby's Horacio Carbonari is unlikely to make his comeback from a back injury. Goalkeeper Mart Poom has still not fully recovered from bruised ribs and although Belgian striker Branko Strupar played in a private friendly this week, he will not be ready.
Last season: Leeds 0 Derby 0, Derby 1 Leeds 1.
Last five league matches: Leeds W W D D W, Derby W L D D L.
Top scorers: Lee Bowyer, Ian Harte, Robbie Keane, Danny Mills, Alan Smith and Mark Viduka (Leeds) all 1 Deon Burton and Fabrizio Ravanelli (Derby) 3.
Match odds: H 4-11 A 8-1 D 13-5.
Referee: A Wiley (Burntwood).
West Ham (20) v Newcastle (4)
Glenn Roeder hopes to have his front-line partnership of Paolo di Canio (ankle) and Frederic Kanoute (hamstring) available after both strikers missed last weekend's defeat at Middlesbrough. New signings Don Hutchison and Tomas Repka could also make home debuts.
Newcastle's French winger Laurent Robert has recovered from a virus but Gary Speed, Wayne Quinn and Aaron Hughes are all out with hamstring injuries while Carl Cort and Kieron Dyer remain long-term absentees. Sylvain Bistin, who made his debut as a late substitute in last Saturday's 4-3 win over Manchester United, is in the squad.
Last season: Newcastle 2 West Ham 1, West Ham 1 Newcastle 0.
Last five league matches: West Ham L L D D L, Newcastle W D D W W.
Top scorers: Paolo di Canio (West Ham) 1 Craig Bellamy (Newcastle) 5.
Match odds: H 6-4 A 6-4 D 21-10.
Referee: P Jones (Loughborough)
Odds supplied courtesy of William Hill