The Denis O'Brien-owned Beacon Hospital is to lodge plans for a 70-bed extension at Sandyford in south Dublin in the coming days.
The new eight-storey hospital extension will also include new A&E and cancer care facilities and associated in-patient treatment rooms.
The planning application, to be lodged with Dún Laoghaire Rathdown County Council, involves the substantive demolition of the eight-storey Beacon Hotel, which the Beacon Hospital purchased late last year from US billionaire John Malone's MHL Collection luxury hotel group.
The Beacon Hospital’s overall investment in the redevelopment scheme, including the purchase of the hotel, is expected to amount to about €75 million.
The expanded hospital is expected to generate 400 new permanent jobs when the extension is operational.
The €75 million investment follows an investment of about €78 million on the hospital over the past six years.
The planning notice published on Friday confirms the 70 care bed extension will provide 5,746 sq m (61,850 sq ft) in space, and the development will also include four apartments for the Beacon One apartments.
The notice by Beacon Hospital Sandyford Ltd states the demolition of the hotel is required in order to facilitate the development.
The planned scheme will also include ancillary administration offices, staff and patient facilities, including a staff and patient cafe and connections to the existing hospital at levels three to eight.
The redevelopment is the largest single investment in the hospital since Mr O’Brien took ownership of the business in 2014.
The extension will increase the number of care beds at the hospital to 269.
The hospital, which opened in 2006, has seen its staff grow from 140 to 1,400 consultants, nurses and healthcare professionals.