Veteran Tory minister Ken Clarke has retired from government, bringing to an end a front-bench career stretching back to 1972 as David Cameron embarked upon a reshuffle of his team ahead of next year's general election.
David Jones was sacked as Welsh secretary, universities minister David Willetts is understood to have stood down and declared his intention to quit as an MP next year while Nick Hurd said he was leaving his post as minister for civil society.
Conservative Big Beast Mr Clarke (74) is stepping down from his role as minister without portfolio.
Former Welsh secretary Mr Jones said he had been asked to stand down by Mr Cameron, who is expected to promote more women into key posts.
“The prime minister is carrying out a reshuffle. He is reshuffling the team and he has asked me to stand down. I totally understand his decision,” said Mr Jones.
‘Wonderful brief’
Mr Hurd announced his departure on Twitter, writing: “Am standing down having been given by DC the rare opportunity to do six years in a wonderful brief. Very proud of what we achieved.
“Thanks to so many friends and critics in our brilliant voluntary sector. You have often driven me nuts but my respect . . . is undimmed.”
A source close to Mr Willetts said he had “indicated a while back that he intended not to fight the next election”.
Earlier Mr Clarke smiled and waved to photographers as he entered No 10 before news of his widely expected exit from the government was confirmed.
“Ken has made the most extraordinary contribution to our public life. In particular I think he was an outstanding chancellor of the exchequer,” said former Tory leader Lord Howard of Lympne.
He told BBC Radio 4's PM programme: "He always speaks his mind. We've been capable of maintaining a friendship over all these years despite the fact that we have quite often disagreed with each other on political issues.
“I think that says a great deal about the kind of person he is.”
Younger talent
Alongside Mr Clarke, the prime minister is also expected to say goodbye to Cabinet veteran Sir George Young and promote a host of younger talent, including some of the stars of the 2010 intake.
Those tipped for advancement include employment minister Esther McVey – who was also seen entering No 10 – education minister Liz Truss and ministerial aide Penny Mordaunt.
Other MPs tipped for promotion include Margot James, Amber Rudd and Harriett Baldwin, as the Tory leader seeks to counter criticism that his government is still dominated by men.
Former defence secretary Liam Fox, a darling of the Conservative right, could make a comeback to the political front line nearly three years after quitting in a row over his special adviser.