David Denton, Jim Hamilton, Matt Scott and Dougie Fife will all start for Scotland against England on Saturday after Vern Cotter made five changes to his starting fifteen.
Outhalf Finn Russell also returns to the Dark Blues line-up for the penultimate RBS Six Nations clash at Twickenham after suspension ruled him out of the 22-19 defeat to Italy at Murrayfield two weeks ago.
Scotland are desperate to restore pride in the Calcutta Cup meeting following three straight defeats to France, Wales and the Azzurri.
Edinburgh number eight Denton — the only player among the incoming five not to have featured in this year’s competition — replaces Johnnie Beattie after shaking off the calf strain which has kept him out of action so far.
Denton’s Gunners team-mates Fife — a try-scorer against France in round one — and Matt Scott replace injured wing Sean Lamont and centre Alex Dunbar, who are both ruled out with knee complaints.
Russell, meanwhile, starts in place of Peter Horne while experienced Saracens lock Hamilton takes the place of benched forward Tim Swinson.
Cotter said: “Jim comes in and will bring his physicality and understanding of English rugby to our forward pack.
“It’s good to have Dave Denton back as he provides us with strong ball-carrying and strong defence. He’s also a very good lineout forward and will give us a bit more physical density against a big forward pack.
“It’s been tough on Finn to sit out and it’s great to have him back. He’s slotted straight back in to the structure we’re looking for.
“Finally, Dougie came on and played well against France and has had a couple of games with his club.
“We’re looking for him to bring his enthusiasm, energy and high work-rate, particularly in kick-chase and receipt.”
Tighthead prop Euan Murray, meanwhile, will equal Allan Jacobsen’s all-time appearance record for a Scotland prop when he collects his 65th cap.
He will partner Alasdair Dickinson and fit-again Ross Ford, who has recovered from the back spasm suffered against Italy to start in an experienced front-row.
Jonny Gray remains in the second-row to pack down with Hamilton, while Blair Cowan and Rob Harley start together for the sixth consecutive time in the backrow, alongside Denton.
Captain Greig Laidlaw will partner the returning Russell from scrumhalf, with the back-line completed by Glasgow Warriors trio Mark Bennett, Tommy Seymour and Stuart Hogg.
Cotter added: “This is a very important game. It will be played away from home at a very intense level and will allow us to assess further our ability to operate away from home in a hostile environment.
“Our focus, however, has been on ourselves and how we can perform better, by identifying the areas that we can control — like improving our skill sets and reinforcing our cohesion — to withstand the difficult times and also apply some pressure.”
SCOTLAND: Stuart Hogg; Dougie Fife, Mark Bennett, Matt Scott, Tommy Seymour; Finn Russell, Greig Laidlaw; Alasdair Dickinson, Ross Ford, Euan Murray; Jim Hamilton, Jonny Gray; Robert Harley, Blair Cowan, David Denton.
Replacements: Fraser Brown, Ryan Grant, Geoff Cross, Tim Swinson, Johnnie Beattie, Adam Ashe; Sam Hidalgo-Clyne, Greig Tonks.
