Saturday (3pm unless stated)
Liverpool (3) v Burnley (12), 12.30pm – Live on BT Sport
Liverpool are without Fabinho following the death of his father. Fellow midfielders Jordan Henderson and Thiago Alcantara could both be in contention for their first appearances of the season following their exploits at Euro 2020.
Burnley will have an unchanged squad for the trip to Anfield. Midfielder Dale Stephens and defender Kevin Long both missed the opening-day defeat to Brighton and they will remain absent as they continue their recoveries following surgery.
Last season: Burnley 0 Liverpool 3; Liverpool 0 Burnley 1
Last five league matches: Liverpool W W W W W; Burnley W L L L L
Top scorers: Mohamed Salah, Roberto Firmino & Diogo Jota (Liverpool) 1; James Tarkowski (Burnley) 1
Match odds: H 1-5 A 14-1 D 11-2
Referee: Mike Dean
Aston Villa (11) v Newcastle (15)
Bertrand Traore is a fresh injury absentee for Aston Villa. The midfielder suffered a hamstring issue during the defeat at Watford and will not be back until after next month's international break.
Newcastle boss Steve Bruce has confirmed Joe Willock will be included in his squad after completing his permanent move to the club from Arsenal. But Jonjo Shelvey has been ruled out after sustaining a fresh calf injury in the opening day home defeat to West Ham.
Last season: Newcastle 1 Aston Villa 1; Aston Villa 2 Newcastle 0
Last five league matches: Aston Villa D L W W L; Newcastle W L W W L
Top scorers: John McGinn & Danny Ings (Aston Villa) 1; Callum Wilson & Jacob Murphy (Newcastle) 1
Match odds: H 4-5 A 10-3 D 14-5
Referee: David Coote
Crystal Palace (18) v Brentford (6)
Conor Gallagher is set to make his competitive debut for Crystal Palace. The Chelsea loanee was ineligible to face his parent club last weekend. James Tomkins is also available after recovering from a knock but Nathan Ferguson (Achilles), captain Luka Milivojevic (personal reasons), Michael Olise (back) and Ebere Eze (Achilles) remain absent.
Brentford have no fresh injury concerns. Denmark midfielder Mathias Jensen has resumed training after recovering from a deep wound in his foot suffered during the Euro 2020 semi-final defeat by England, but is not yet in contention.
Last season: No corresponding fixture
Last five league matches: Crystal Palace L W L L L; Brentford W W W W W
Top scorers: Crystal Palace none; Sergi Canos (Brentford) 1, Christian Norgaard (Brentford) 1
Match odds: H 17-10 A 9-5 D 21-10
Referee: Martin Atkinson
Leeds (20) v Everton (5)
Kalvin Phillips could make his first appearance of the season for Leeds. Left back Junior Firpo, a €15.75 million summer signing from Barcelona, is aiming to make his full Premier League debut.
James Rodriguez will be absent again for Everton, but Moise Kean can be called upon. Goalkeeper Andy Lonergan has joined on a deal until the end of the season.
Last season: Leeds 1 Everton 2; Everton 0 Leeds 1
Last five league matches: Leeds W W W W L; Everton D L W L W
Top scorers: Luke Ayling (Leeds) 1; Richarlison (Everton) 1
Match odds: H 13-10 A 2-1 D 5-2
Referee: Darren England
Manchester City (13) v Norwich (19)
Kevin De Bruyne is a doubt for Manchester City. The Belgium playmaker, who came off the bench in last Sunday's 1-0 loss at Tottenham, has been troubled by an ankle problem and did not train on Friday.
Norwich are expected to be without defender Christoph Zimmermann through illness. Young Irish centre back Andrew Omobamidele is back in full training again following tonsillitis, so could come into contention, along with winger Onel Hernandez, who has been building up fitness after an enforced lay-off because of Covid-19.
Last season: No corresponding fixture
Last five league matches: Man City L W L W L; Norwich L W W D L
Top scorers: Man City none; Norwich none
Match odds: H 1-10 A 25-1 D 17-2
Referee: Graham Scott
Brighton (8) v Watford (7), 5.30m – Live Sky Sports
Republic of Ireland forward Aaron Connolly is back in contention for Brighton after missing last weekend's win at Burnley due to "personal reasons" but Danny Welbeck and Tariq Lamptey remain sidelined with hamstring problems and Joel Veltman will miss out due to self-isolation.
Josh King could be in line for his Watford debut after recovering from a minor groin injury. Kiko Femenia is also available after building up his fitness but midfielder Juraj Kucka is expected to miss out with a thigh injury.
Last season: No corresponding fixture
Last five league matches: Brighton L D W L W; Watford W W L W W
Top scorers: Alexis Mac Allister & Neal Maupay (Brighton) 1; Ismaila Sarr, Emmanuel Bonaventure & Juan Hernandez (Watford) 1
Match odds: H 8-11 A 9-2 D 12-5
Referee: Anthony Taylor
Sunday (2pm unless stated)
Southampton (16) v Manchester United (1) – Live Sky Sports
Southampton have no fresh injury concerns. Saints boss Ralph Hasenhüttl has a near fully-fit squad but will not be able to call on the services of Irish midfielder Will Smallbone (knee).
New signing Raphael Varane is pushing to make his Manchester United debut at St Mary’s but goalkeeper Dean Henderson is still building fitness after contracting coronavirus. The 28-year-old defender was not signed in time to play against Leeds last weekend but has impressed since arriving, while striker Edinson Cavani has also been training after returning from an extended summer break.
Last season: Man Utd 9 Southampton 0; Southampton 2 Man Utd 3
Last five league matches: Southampton W W L L L; Man Utd L L D W W
Top scorers: Adam Armstrong (Southampton) 1; Bruno Fernandes (Man Utd) 3
Match odds: H 24-5 A 4-7 D 16-5
Referee: Craig Pawson
Wolves (14) v Tottenham (10)
Bruno Lage's maiden home game as Wolves boss could see Raul Jimenez make his first competitive appearance at Molineux for nine months. The striker returned after recovering from a fractured skull as Wanderers began the season with a 1-0 defeat at Leicester last weekend. The Mexico international is expected to keep his place in the starting line-up.
Tottenham will make a decision whether to include wantaway striker Harry Kane after Saturday’s training session as Nuno Espirito Santo returns to Molineux.
Last season: Tottenham 2 Wolves 0; Wolves 1 Tottenham 1
Last five league matches: Wolves W L L L L; Tottenham L W L W W
Top scorers: Wolves none; Son Heung-min (Tottenham) 1
Match odds: H 23-10 A 13-10 D 11-5
Referee: Stuart Attwell
Arsenal (17) v Chelsea (2), 4.30pm – Live Sky Sports
Arsenal could welcome back captain Pierre-Emerick Aubameyang after he missed the 2-0 loss at Brentford through Covid-19 along with Alexandre Lacazette, Alex Runarsson and Willian. Willian could also return but Lacazette and Runarsson are still missing, while new signing Martin Odegaard is not available as he awaits a visa.
Christian Pulisic will miss out for Chelsea after testing positive for Covid-19. Midfielders Hakim Ziyech (shoulder) and N’Golo Kante (ankle) could return, while €115 million recruit Romelu Lukaku may make his second Chelsea debut.
Last season: Chelsea 0 Arsenal 1; Arsenal 3 Chelsea 1
Last five league matches: Arsenal W W W W L; Chelsea W L W L W
Top scorers: Arsenal none; Trevoh Chalobah, Marcos Alonso, Hakim Ziyech & Christian Pulisic (Chelsea) 1
Match odds: H 15-4 A 4-5 D 5-2
Referee: Paul Tierney
Monday
West Ham (4) v Leicester (9), 8pm – Live Sky Sports
Arthur Masuaku is West Ham's only injury absentee. The wing back is still building up his fitness following the knee operation he underwent last season.
Leicester remain without Wesley Fofana, Jonny Evans and Ryan Bertrand. Fofana suffered a fractured fibula during a recent friendly against Villarreal, while Evans is still recovering from a foot problem. Bertrand is ruled out after testing positive for Covid-19 ahead of the season-opening win over Wolves.
Last season: West Ham 3 Leicester 2; Leicester 0 West Ham 3
Last five league matches: West Ham L D W W W; Leicester L W L L W
Top scorers: Said Benrahma, Michail Antonio, Tomas Soucek & Aaron Cresswell (West Ham) 1; Kelechi Iheanacho & Jamie Vardy (Leicester) 1
Match odds: H 8-5 A 17-10 D 12-5
Referee: Michael Oliver
