Former captain Steve Borthwick has been dropped from England's 32-man elite squad for the forthcoming season and replaced by the uncapped Gloucester lock Dave Attwood.
England manager Martin Johnson has also axed wing Ugo Monye and centre Mathew Tait while lock Louis Deacon and hooker Lee Mears join them in being relegated to the second-string Saxons squad.
Leicester scrum-half Ben Youngs and prop Dan Cole are officially promoted into the seniors after establishing themselves in the Test team during England's tour of Australia and New Zealand.
Wasps' uncapped centre Dominic Waldouck has also been included along with Leeds flanker Hendre Fourie and Gloucester prop Paul Doran-Jones.
Borthwick's fall from grace has been rapid and it represents a marked change in direction from Johnson and the England management.
Johnson had stood by Borthwick in the face of widespread criticism over the last two years and the Saracens lock captained England for 20 consecutive Tests until he was sidelined by a knee injury.
Borthwick, 30, missed England's RBS 6 Nations game against France followed by the summer Test series against Australia - and he has now paid the ultimate price.
From being a captain with 57 caps, Borthwick is now not considered to be among the top four locks in England with Attwood joining Tom Palmer, Courtney Lawes and the veteran Simon Shaw.
Lewis Moody successfully assumed the captaincy becoming only the second man - after Johnson in 2003 - to lead England to a Test win over the Wallabies in Australia.
Fitness permitting, the Bath-bound flanker is now set to captain England into the 2011 Rugby World Cup - while Borthwick is fighting just to make the plane.
Johnson said: "Leaving Steve Borthwick out was a very hard decision.
"He's done a fantastic job for England over the last couple of years and it's the most difficult call we've had to make.
"It is very tough on Steve but it goes to show the depth of talent we've got in that area.
"We want to build on what we've done this summer and a southern hemisphere tour that was hugely beneficial and a really positive experience for the group.
"We were able to give lots of opportunities to players and expose them to a high level of rugby."
Lawes brought a new dynamic edge to England's second row in the victory over Australia while Attwood impressed Johnson with his hard-edged performances for the midweek team.
Mears and Monye both played Test rugby for the British and Irish Lions last summer but have been dropped to the Saxons after struggling to recapture their best form.
George Chuter overtook Mears in the pecking order during England's tour while David Strettle and Matt Banahan were both preferred to Monye.
Tait has never succeeded in establishing himself in the England squad under Johnson and he has lost out to Waldouck.
Johnson had never seen Doran-Jones play when he was drafted into the squad as emergency cover in November but scrum coach Graham Rowntree named him as England's most improved player on tour.
His inclusion means there is no place for Phil Vickery, though loosehead Andrew Sheridan has been included after recovering from a shoulder injury.
England's 32-man elite player squad for the 2010/11 season:
FORWARDS:D Attwood (Gloucester), G Chuter (Leicester), D Cole (Leicester), T Croft (Leicester), P Doran-Jones (Gloucester), N Easter (Harlequins), H Fourie (Leeds), D Hartley (Northampton), J Haskell (Stade Francais), C Lawes (Northampton), L Moody (Bath), T Palmer (Stade Francais), T Payne (Wasps), S Shaw (Wasps), A Sheridan (Sale Sharks), S Thompson (Leeds), D Wilson (Bath), J Worsley (Wasps).
BACKS:D Armitage (London Irish), C Ashton (Northampton), M Banahan (Bath), D Care (Harlequins), M Cueto (Sale Sharks), T Flood (Leicester), R Flutey (Wasps), B Foden (Northampton), S Hape (Bath), D Strettle (Saracens), M Tindall (Gloucester), D Waldouck (Wasps), J Wilkinson (Toulon), B Youngs (Leicester).
England Saxons squad for the 2010/11 season:
FORWARDS:S Armitage (London Irish), D Bell (Bath), S Borthwick (Saracens), A Corbisiero (London Irish), J Crane (Leicester), L Deacon (Leicester), P Dowson (Northampton), J Golding (Newcastle), L Mears (Bath), M Mullan (Worcester), L Narraway (Gloucester), G Parling (Leicester), T Rees (Wasps), C Robshaw (Harlequins), A Saull (Saracens), D Ward-Smith (Wasps), R Webber (Wasps), T Wood (Northampton).
BACKS:N Abendanon (Bath), A Allen (Leicester), B Barritt (Saracens), S Geraghty (Northampton), A Goode (Saracens), D Hipkiss (Leicester), P Hodgson (London Irish), C Hodgson (Sale Sharks), U Monye (Harlequins), S Myler (Northampton), J Simpson (Wasps), J Simpson-Daniel (Gloucester), M Tait (Sale Sharks), R Wigglesworth (Saracens).