Enterprise:State support for non-agricultural or tourism business is to be sharply reduced because of EU constraints, according to the plan.
However, during the period of the plan it is intended to spend €3.3 billion in supporting indigenous and foreign enterprise.
The indigenous enterprise sub-programme in the plan is to see €1.69 billion in support for a number of key areas.
Investment in the development of foreign enterprises is scheduled to be €1.63 billion.
Overall the State is to focus on areas where Ireland could become an "internationally significant location" for foreign direct investment.
For indigenous industry the State is to focus on building knowledge-based, innovative, sustainable and competitive activities.
Infrastructural development, support for science, and a favourable tax regime will also provide support for enterprise, according to the report. The challenges facing the sector include loss of competitiveness in recent years, and the reductions in permissible State supports that are to apply from this year.
Lack of scale for indigenous industry is a key issue, according to the report. There is a need for improved management skills and the development of international marketing and sales capabilities.
Key areas to be targeted include high potential start-ups, improving management and international sales capabilities, and aiding access to appropriate finance and equity. Enterprise Ireland is to play a key role.
For foreign direct investment, the plan said, IDA Ireland is to concentrate on creating an overall "business biosystem" that will attract investment and stimulate development.
Spending will be by way of such financial products as employment and research grants, and client services such as facilitation, information and advice.
Existing companies are to be supported in moving up the value chain. Ireland will seek to develop niches in which it can carve out world market leadership.
It will also seek to promote relationships between foreign companies operating here and local educational and research institutions.
The plan envisages increased spending on research grants and the creation of jobs where third-level graduates are required.
Policy is to shift towards attracting very highly-skilled workers for knowledge intensive sectors, where starting salaries will be high and career prospects good.