Gavin Henson's hopes of a Six Nations comeback for Wales have been hit by injury.
The 25-year-old, overlooked by coach Gareth Jenkins for the first two matches of the tournament, had an opportunity to force his way back into the side after Kevin Morgan sustained a broken jaw in the 21-9 defeat to Scotland
But Henson has sustained a knee injury which has now ruled him out of Ospreys' Magners League match at home to Connacht tomorrow - seven days before Wales face France in the Six Nations.
"Inflammation has come up on the knee this week," Ospreys' director of rugby Kevin Hopkins said.
"Gavin has had a few bumps on it this season. Our physios have assessed him and the knee is not right. We are not in a position to play players when they are not 100 per cent."
Ospreys' next match is in Edinburgh on March 2nd - eight days before Wales travel to Italy.