Leinster winger Shane Horgan will equal Reggie Corrigan's record of 61 Heineken Cup appearances if, as expected, he features against Toulouse on Sunday.
The Ireland star scored the only try of the game in the impressive home win over Leicester last weekend and is one of 12 internationals named in the Leinster squad for this week's away game.
Brian O'Driscoll, Leo Cullen, Gordon D'Arcy, Girvan Dempsey, Luke Fitzgerald, Keith Gleeson, Jamie Heaslip, Bernard Jackman, Shane Jennings, Rob Kearney and Ireland's most capped player, Malcolm O'Kelly are all included..
Felipe Contepomi, who passed 300 career points in the competition with his 17-point haul in last weekend's victory, is also selected by coach Michael Cheika.
Sunday's Pool 6 clash at the Stade Toulousain kicks-off at 8pm Irish time.
Connacht show four changes to their 22 man squad for the European Challenge Cup second round clash with Cetransa El Salvador at the Sportsground on Friday (6.30pm).
Ronan Loughney and Daniel Riordan have both overcome injuries and are included.
Joe Merrigan and Andrew Browne are also included as Michael Bradley's men look to get back on track in Pool 3 following last weekend's 15-6 loss to Brive.
"We have been a away a lot since the start of this season and this game will be the first of four successive home matches," said Bradley.
"It will be a key period for us and we want to kick that off with a resounding victory on Friday evening," he said.
Leinster squad: Ollie le Roux, Stan Wright, Brian Blaney, Bernard Jackman, Juan Francisco Gomez, Stephen Knoop, Leo Cullen, Cameron Jowitt, Malcolm O'Kelly, Stephen Keogh, Kevin McLaughlin, Keith Gleeson, Shane Jennings, Jamie Heaslip, Chris Whitaker, Cillian Willis, Felipe Contepomi, Jonathan Sexton, Christian Warner, Michael Berne, Luke Fitzgerald, Rob Kearney, Gordon D'Arcy, Brian O'Driscoll, Shane Horgan, Gary Brown, Girvan Dempsey
Connacht squad: Andrew Browne, Tim Donnelly, Gavin Duffy, Peter Durcan, Andrew Farley, Adrian Flavin, Ronan Loughney, Keith Matthews, Michael McCarthy, Conor McPhillips, Joe Merrigan, Robbie Morris, John Muldoon, John O'Connor, Ray Ofisa, Conor O'Loughlin, Daniel Riordan, Michael Swift, Ofisa Treviranus, Brett Wilkinson, Aidan Wynne, Darren Yapp.
