Republic of Ireland boss Martin O'Neill will be without Everton full back Séamus Coleman and goalkeeper Shay Given for next Saturday's European Championship qualifier against Gibraltar at the Aviva Stadium.
Coleman missed Sunday's 2-1 defeat to Manchester United and has not played since suffering concussion in the Europa League win over Wolfsburg on September 18th.
Everton manager Roberto Martinez believes the Donegal-born defender will also miss the trip to Gelsenkirchen to play world champions Germany next Tuesday, but there has been no confirmation yet from the FAI.
They have confirmed that veteran goalkeeper Shay Given will miss the game against Gibraltar with a hip injury.
Republic of Ireland manager Martin O’Neill is unlikely to call up a replacement for the 28-year-old as he had named four goalkeepers in his 27-man reduced squad on Saturday for the game against Gibraltar.
Republic of Ireland squad to face Gibraltar (25)
Goalkeepers: David Forde; Keiren Westwood; Rob Elliot
Defenders: Richard Keogh; Marc Wilson; John O'Shea; Alex Pearce; Ciaran Clark; Stephen Ward
Midfielders: Jeff Hendrick; Glenn Whelan; Darron Gibson; Aiden McGeady; Jon Walters; Anthony Pilkington; James McClean; Robbie Brady; Stephen Quinn; David Meyler; Wes Hoolahan
Forwards: Robbie Keane; Shane Long; Daryl Murphy; Kevin Doyle; Anthony Stokes